Protein structures by spallation neutron crystallography

نویسندگان

  • Paul Langan
  • Zoë Fisher
  • Andrii Kovalevsky
  • Marat Mustyakimov
  • Amanda Sutcliffe Valone
  • Cliff Unkefer
  • Mary Jo Waltman
  • Leighton Coates
  • Paul D. Adams
  • Pavel V. Afonine
  • Brad Bennett
  • Chris Dealwis
  • Benno P. Schoenborn
چکیده

The Protein Crystallography Station at Los Alamos Neutron Science Center is a high-performance beamline that forms the core of a capability for neutron macromolecular structure and function determination. This capability also includes the Macromolecular Neutron Crystallography (MNC) consortium between Los Alamos (LANL) and Lawrence Berkeley National Laboratories for developing computational tools for neutron protein crystallography, a biological deuteration laboratory, the National Stable Isotope Production Facility, and an MNC drug design consortium between LANL and Case Western Reserve University.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Fifteen years of the Protein Crystallography Station: the coming of age of macromolecular neutron crystallography

The Protein Crystallography Station (PCS), located at the Los Alamos Neutron Scattering Center (LANSCE), was the first macromolecular crystallography beamline to be built at a spallation neutron source. Following testing and commissioning, the PCS user program was funded by the Biology and Environmental Research program of the Department of Energy Office of Science (DOE-OBER) for 13 years (2002...

متن کامل

Atomic pair distribution function analysis from the ARCS chopper spectrometer at the Spallation Neutron Source

Neutron powder diffraction based atomic pair distribution functions (PDFs) are reported from the new wide angular-range chopper spectrometer ARCS at the Spallation Neutron Source (SNS) at Oak Ridge National Laboratory (ORNL). The spectrometer was run in white-beam mode with no Fermi chopper. The PDF patterns of Ni and Al2O3 were refined using the PDFfit method and the results compared to data c...

متن کامل

Hydrogen atoms can be located accurately and precisely by x-ray crystallography

Precise and accurate structural information on hydrogen atoms is crucial to the study of energies of interactions important for crystal engineering, materials science, medicine, and pharmacy, and to the estimation of physical and chemical properties in solids. However, hydrogen atoms only scatter x-radiation weakly, so x-rays have not been used routinely to locate them accurately. Textbooks and...

متن کامل

Synchrotron-driven Spallation Sources

The use of synchrotrons for pulsed neutron spallation sources is an example of spin-off from the accelerator development prompted by particle physics. The first proposal for an accelerator-driven source with a thermalised neutron facility was in the 1960s (Intense Neutron Generator, ING) [1], but this project was never built. There was earlier work on 'electrical' breeders [2] and the direct bo...

متن کامل

Opportunities and challenges with the growth of neutron crystallography.

Neutron crystallography is a newly blossoming field of structural biology. As described in the historical account given by Benno Schoenborn in this issue, its origins can be traced back to the Cambridge MRC tearoom in 1965 when it was discussed as the only plausible experimental method for directly determining the location of H atoms in proteins. Knowing the location of H atoms can provide info...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Journal of Synchrotron Radiation

دوره 15  شماره 

صفحات  -

تاریخ انتشار 2008